LABORATORY OF RICHARD LEVIS

Department of Molecular Biophysics & Physiology

Richard Levis is interested in ionic channels, voltage gated ionic channels, signal detection and electrophysiology. He has developed a number of innovative techniques to investigate the behavior of ion channels. Recently he has pioneered low noise current recording techniques for patch clamp. Research in collaboration with J. Tang and R.S. Eisenberg involves measurements of large conductance channels with significantly improved time resolution and bandwidth to measure the time required for conformational changes between open and closed states. In collaboration with K. Lynn and S. Jovanovic of Brookhaven National Laboratory (Upton, NY) and R.S. Eisenberg,. Dr. Levis has also been involved in the development of an instrument which detects and measures single channel currents in real time. Amplitude information, mean open an closed times, and histograms of open and closed durations are presented in real time, allowing far more rapid and efficient experimentation.

Hainsworth AH., Levis RA. and Eisenberg RS. 1994. Origins of open-channel noise in the large potassium channel of sarcoplasmic reticulum. J Gen Physiol. 104, 857-83.

Levis RA. and Rae JL. 1993. The use of quartz patch pipettes for low noise single channel recording. Biophys J. 65, 1666-77.

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